The most common side effects of CYRAMZA when given by itself include:
- Low blood platelet count
- Feeling tired
- Low albumin (protein in the blood)
- Low sodium in the blood
- Swelling in the arms, legs, hands, or feet
- High blood pressure
- Stomach pain
- Low white blood cell count
- Not feeling hungry
- Too much protein in the urine
- Feeling like you want to throw up (vomit)
- Unusual buildup of fluid in the belly
- Low calcium in the blood
- Headache
- Diarrhea
- Nose bleeds
- Trouble falling or staying asleep
- Fever
- Vomiting
- Back Pain
The most common serious side effects of CYRAMZA when given by itself include:
- Anemia (a decrease in red blood cells)
- Blocked digestive tract
- Unusual buildup of fluid in the belly
- Pneumonia (infection of one or both lungs)
Some people needed to have extra red blood cells put into their blood.
The most common side effects of CYRAMZA when given with certain chemotherapy medicines include:
- Low white blood cell count
- Diarrhea
- Tiredness
- Mouth sores with or without swelling in the lining of the mouth
- Decreased appetite
- Nose bleeds
- Low blood platelet count
- High blood pressure
- Swelling in the arms, legs, hands, or feet
- Too much protein in the urine
- Low white blood cell count with a fever
- Swelling, redness, or pain in the palms or soles (hand-foot syndrome)
- Increased production of tears
- Bleeding in the digestive tract
- Low albumin (a protein in the blood)
The most common serious side effects of CYRAMZA when given with certain chemotherapy medicines include:
- Low white blood cell count with a fever
- Pneumonia
- Low white blood cell count
- Diarrhea
- Blocked digestive tract
Some people needed treatment to increase their white blood cell counts.
The most common side effects of CYRAMZA when given with erlotinib include:
- Infections
- Increased levels of liver enzymes
- Diarrhea
- High blood pressure
- Low red blood cell count
- A sore or inflammation inside the mouth
- Low blood platelet count
- Loss of hair
- Nosebleeds
- Too much protein in the urine
- Decrease in a type of white blood cell
- Low potassium in the blood
- Swelling in the arms, legs, hands, and feet
- Headache
- Gastrointestinal bleeding
- Gums bleeding
- Bleeding in the lungs or respiratory tract
The most common serious side effects of CYRAMZA when given with erlotinib include:
- Pneumonia (infection in one or both lungs)
- Skin infection (bacterial infection under the skin)
- Collapsed lung (air or other gas in the pleural cavity in the lungs)
Some people needed to have extra red blood cells put into their blood.
These are not all the possible side effects of CYRAMZA. Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or
www.fda.gov/medwatch.